Theophylline is available by prescription in 100 mg, 200 mg, 300 mg, and 400 mg, Extended Release (ER), tablets. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. … old dogs reported at least one category consistent with Cognitive Dysfunction Syndrome and this rose to 68% for dogs 15-16 years of age. This medication is also used to treat congestive heart failure and pulmonary edema. Therefore, in a patient who has received no theophylline in the previous 24 hours, a loading dose of intravenous theophylline of 4.6 mg/kg (5.7 mg/kg as aminophylline), calculated on the basis of ideal body weight and administered over 30 minutes, on average, will produce a maximum post-distribution serum concentration of 10 mcg/mL with a range of 6-16 mcg/mL. Theophylline in the past and present. A blood sample should usually be taken 4–6 hours after an oral dose of a modified-release preparation (sampling times may vary—consult local guidelines). Keep all appointments for testing the blood level. The aminophylline infusion regimen was then adjusted to provide a supratherapeutic level of theophylline of 34 micrograms X ml-1 (A2) and the ADE was reassessed. Free E-newsletter Subscribe to Housecall. Why has my veterinarian prescribed Aminophylline? Theophylline is metabolized primarily in the liver (in … No study to date has evaluated the effects of an inhaled beta … Actually there are several substitutes: 1) Aminophylline, 2) Terbutaline. The usual … Ann Intern Med 1982 May;96(5):684. Theophylline comes as a tablet, capsule, or liquid to take by mouth. Then I was given a prescription for Uniphyl. Constricted airways and mucus build up are two of the main culprits behind difficult breathing. Pick up or refill now. It’s given directly into a vein (intravenously) to help relieve your asthma symptoms if an attack of breathlessness or an asthma attack has started. Theophylline is a widely used, effective bronchodilator that can be prescribed by your veterinarian. Even with aminophylline injection still commonly used, the ethylenediamine only serves to increase pH sufficiently to dissolve theophylline at the packaged concentration. … The usual dose in dogs is 4.5 to 6.8 mg/lb every 12 hours. After you or your child begin taking theophylline, it is very important that your doctor check the level of the medicine in the blood at regular intervals to decide if the dose needs to be changed. It is a … 6.Fenje PC, Isles AF, Baltodano A, MacLeod SM, Soldin S. Interaction of cimetidine and theophylline in … * (phosphoric diester hydrolase) inhibitor, an anti-asthmatic drug, an anti-inflammatory agent, an immunomodulator, an … Side Effects . A fluoroscopic examination was performed to diagnose and grade TC. The volume of distribution in cats is reported to be 0.46 L/kg, and in horses, 0.85 – 1.02 L/kg. Theophylline … It usually is taken every 6, 8, 12, or 24 hours. Do not take more or less of it or take it more often than … Inhaled corticosteroids are the preferred asthma maintenance treatment during pregnancy due to the potential toxicities of theophylline and the propensity for drug interactions that can reduce theophylline clearance. [31822] If theophylline or aminophylline must be used, it is recommended that serum theophylline concentrations be regularly monitored and maintained … Theophylline comes as an extended-release (long-acting) tablet, extended-release capsule, and a solution (liquid) to take by mouth. 1988; 94: 10S. Drug information provided by: IBM Micromedex. You’ll only ever be given theophylline intravenously if you’re in hospital (usually in the form of aminophylline). Common side effects may include stomach pain, diarrhea, upset stomach, headache, sweating, insomnia or nervousness. 1983). Learn who it’s for, how it works, its side effects, warnings, and more. Theophylline is also used in management of intrathoracic collapsing trachea and various forms of canine bronchitis, but it is less effective than glucocorticoids such as prednisone. Theophylline is an oral medication used to treat asthma and other lung diseases. The medication should be administered on an empty stomach and food should be given an hour after the administration of the medication. I spent several hours taking breathing treatments each day. The ADE was significantly … The recommended doses for bronchodilatation are 200 to 400 mg twice daily, but one-half of these doses may be effective as an antiinflammatory treatment. The doctor or nurse who gives it to you will make sure you get the … Take theophylline exactly as directed.   The lowest dose able to achieve a therapeutic effect … For pet owners: Pick up and fill a new prescription for your pet or refill a current … Because of the low volumes of distribution and theophylline’s low lipid solubility, obese patients should be dosed on a lean body weight basis. The volume of distribution of theophylline for dogs has been reported to be 0.82 L/kg. It opens the lung's air passages by relaxing the muscles in the lungs and chest. from aminophylline to theophylline in preterm infants Reese J, Prentice G, Yu VJ. Theophylline injected solution is available in a 25 mg/1 mL formulation for use in emergency situations. The original online version of this article included the following incorrect sentence in its abstract: ‘Serum theophylline concen- trations remained unchanged in 18 … Plasma-theophylline concentration is measured 5 days after starting oral treatment and at least 3 days after any dose adjustment. Google Scholar ; reported accelerated intracardiac conduction in dogs given a toxic dose of aminophylline, and were able to induce ventricular fibrillation in three of eight dogs so treated. It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4. My doctors couldn't find any medication that would help. Age-related behavioural changes may be … Everything changed for me when I started taking it. Uniphyl (theophylline) for Asthma, acute: “My Asthma came back when I was around 45 years old. Chronic theophylline overdose has minimal gastrointestinal clinical effects. Theophylline is a drug that has been in use for asthma since the 1950's. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Theophylline is typically used more often in dogs than cats, given variable efficacy and, perhaps, less need for chronic bronchodilator therapy in cats. It was so bad I couldn't go outside or open a door in the house. Therefore, if you give a pet cimetidine and one of these other drugs (theophylline, aminophylline, lidocaine, and diazepam, to name a few), it is more likely that a pet will develop side effects similar to those seen with overdoses of the drug in question. Seizures, hypotension, and significant dysrhythmias usually are observed when serum levels approach 80 mcg/mL. This is a medication that controls symptoms but doesn’t cure them. Forty-seven dogs with TC that received theophylline-based therapy during 2013-2017 were investigated. The rate of absorption from modified-release … Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.   The recommended dosage varies by age as well as the intended use. It does not provide medical advice, … COPD News Today is strictly a news and information website about the disease. Only 12% of owners voluntarily reported signs of CDS to their Veterinary Surgeon. Theophylline should be administered 2 to 3 times a day and the suggested dosage for dogs is 2.25 to 5 grams of medication per pound of weight of the pet. It may also be used with other medications in the treatment of cardiac disease. Aminophylline Capsule Prescribed For: Dogs and Cats May be Prescribed For: Bronchospasm and Cardiogenic Pulmonary Edema If you have any questions concerning these medications, please consult with your doctor. Moreover, due to differences in concentration between aminophylline (25 mg/mL) and theophylline (0.8 mg/mL), it becomes impractical to administer more than 50 mg of theophylline as a single dose, equivalent to roughly 60 mg of aminophylline… Our general interest e-newsletter keeps you up to date on a wide variety of health topics. In human, two multicenter, double-blind, randomized trials, carried out in 21 Italian pulmonary clinics to investigate the therapeutic efficacy and tolerability of doxofylline compared to slow-release theophylline or aminophylline, demonstrated that doxofylline is an effective and well tolerated agent in patients suffering from chronic reversible airways obstruction [16,17]. Prescribing and dispensing information . In a second study 75% of owners of dogs 7 years reported one or more behavioural signs consistent with CDS. These are both bronchodilators, just like Theophylline. Seizures were more commonly reported with acute overdose than with chronic overdose. Do not take … Intra-arterial aminophylline infusion inhibited AmB-induced acute vasoconstriction in dogs (Gerkens et al. Several sustained-release preparations of theophylline and aminophylline that are absorbed at a constant rate provide steady plasma concentrations over a 12- to 24-hour period . Sections. 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